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Beilstein J. Org. Chem. 2019, 15, 623–632, doi:10.3762/bjoc.15.58
Graphical Abstract
Figure 1: Leishmania lipophosphoglycan (LPG), with Gal-β-(1→4)-[Man-α-(1→2)-Man-α-(1→2)-Man] variant capping ...
Figure 2: Pathogen-associated bioerodible microparticles 2 and trimannose-coated latex beads 1.
Figure 3: General design of the bioerodible microparticles.
Scheme 1: Synthesis of fluorous CbzF-protected aminopentanol spacer 7.
Scheme 2: Iterative synthesis of α-1,2-trimannose 16. Reagents and conditions: a) 1 M NaOH, MeOH or NaOMe.
Scheme 3: Synthesis of bioerodible microparticle 2. Reagents and conditions: a) Et2NH, CH3CN, b) CH2Cl2/TFE/A...
Figure 4: Trimannose-linked bioerodible microparticle 2 treatment of Leishmania major infected wild-type and ...